Correspondence to Author: Liping Lai ¹ , Hong Wang ² , Fanyuan Li ¹ , Shanrong Shu^1*. 

1.Department of Gynecology and Obstetrics, The First Affiliated Hospital of Jinan University, 510630, Guangzhou, People’s Republic of China
2.Department of Gynecology and Obstetrics. Guangzhou Nansha District maternal and child health hospital, 511466, Guangzhou, People’s Republic of China

DOI: 10.52338/wjoncgy.2026.5551

Abstract:

Purpose:Nowadays the diagnosis of ovarian endometriosis is mainly through laparoscopy. The purpose of this study is to explore the clinical value of multiple noninvasive tests such as carbohydrate antigen 125 (CA125), inflammatory factors and coagulation indexes in the diagnosis of ovarian endometriosis.
Methods: We retrospectively analyzed the general clinical data, inflammatory factors, coagulation indexes and CA125 of patients in our hospital. SPSS26.0 and R4.2.2 were used for statistical analysis
Results:CA125 and prothrombin time (TT) were statistically different between ovarian endometriosis and control groups (p<0.05). Correlation analysis showed that CA125, fibrinogen (FIB) and lymphocyte count were positively correlated with the stage (p<0.05). The diagnostic value of CA125, TT and combined-markers was compared using receiver operating characteristic (ROC) curves. The area under the curve (AUC) of CA125, TT and the combined-marker were 0.819, 0.601 and 0.714 respectively, with the sensitivity 82.9%, 36.8% and 59.0% respectively, the specificity 75.9%, 80.2% and 79.2% respectively.
Conclusion: TT is associated with the occurrence and has no relation with stage. FIB was related to the stage. The model established by CA125 and TT has good predictive value in the diagnosis of ovarian endometriosis..

Keywords: Ovarian endometriosis, Carbohydrate antigen 125, Fibrinogen, Thrombin time.

Citation:

Dr. Shanrong Shu,The Clinical Value Of Inflammatory Factors, Coagulation Indexes And Ca125 In The Diagnosis Of Ovarian Endometriosis. World Journal of Medical Oncology 2026.