Correspondence to Author: Olatunji BI (MD)^I, Olaleye OO (PHD)^II, McNeil RTO (PHD)^III. 

I * Department of Anatomy and Histology, Sefako Makgatho Health Science University, Ga-Rankuwa .Email: giftandjoy01@gmail.com. Phone: 061 966 7054.
11* Dept of Oral Biological Sciences, Faculty of Health sciences, University of the Witwatersrand Medical School, Johannesburg South Africa Olatunbosun. Email: Olaleye@wits.ac.za Phone: 078 742 2147
111* Department of Human Anatomy, Faculty of Basic Medical sciences, College of Medicine, University of Jos Nigeria. Phone: 071 975 9167. Email: rosiemcneil@gmail.com

DOI: 10.52338/wjoncgy.2025.4914

Abstract:

Introduction:In addition to some studies which suggested that Efavirenz [EFV] may have anti-proliferative effects on various cancer cell lines even at sub-therapeutic doses, EFV has been reported to strongly impact angiogenesis and disrupt neutral lipid homeostasis. The aim of this paper is to bring to light the potential role Intratumoral Microvessel Density (MVD) holds in understanding the Antiangiogenic Effects of Efavirenz on oral cell cancer. .
Aims and objectives: To focus attention on the potential role Intratumoral Microvessel Density (MVD) holds in understanding the Antiangiogenic Effects of Efavirenz on oral cell cancer.
Methods: This paper aims to draw attention on the Intratumoral Microvessel Density (MVD) as a potential factor in understanding the Antiangiogenic Effects of Efavirenz on oral cell cancer.
Results: Our data analysis revealed that EFV treatments did not exhibit significant main effects on the viability of the cancer cell line (F (6,20) = 0.7970; p =0.5878). One-way Analysis of Variance (ANOVA) was used to determine the efficacy of the drug, at 0.05 significance level (p ≤ 0.05).
Discussion/Conclusion: The results indicate that Efavirenz holds promise as an anti-proliferative agent for treating oral cancer. Nevertheless, additional research is necessary to fully explain the impact of the Intratumoral Microvessel Density (MVD) in understanding the Antiangiogenic Effects of Efavirenz on oral cell cancer.

Keywords:Cal 27 cells ; Efavirenz; anti-mitotic; oral squamous cell; anti-angiogenic; AIDS -defining cancers; anti-proliferative; Apoptosis.

Citation:

Dr. Olatunji BI, Oral Cell Cancer: Could Intratumoral Microvessel Density (MVD) Hold the Key to Understanding the Antiangiogenic Effects of Efavirenz?. World Journal of Medical Oncology 2025.