Authors:

Ana Kulić^1,*, Helena Penić-Grgaš^2,*, Maja Sirotković- Skerlev^1,5, Natalija Dedić Plavetić^3,5, Stjepko Pleština^3,5, Filip Sedlić ^1,5, Daria Pašalić^4,5

¹Department of Oncology, Divison of Pathophysiology and Experimental Oncology, University Hospital Center Zagreb, Croatia
²Zagreb Emergency Medicine Service, Zagreb, Croatia
³Department of Oncology, Division of Medical Oncology, University Hospital Center Zagreb, Croatia
⁴Department of Medical Chemistry, Biochemistry and Clinical Chemistry
⁵School of Medicine, University of Zagreb, Croatia *These authors contributed equally

DOI: https://doi.org/10.52338/wjoncgy.2022.1007

Abstract:

Metabolomics is a systems approach in medical research that aims to quantitatively analyze small molecules (less than 1500 Da) in a given biospecimen. Improvement in analytical technologies enabled metabolic research in various fields of medicine including oncology. Metabolic reprogramming is a firmly established hallmark of cancer. It includes changes in tumor cells and in the stromal cells as well. In this review, we focus on metabolomics in the field of cancer research. In the first part, we discuss the main technical approaches. In the second part, we address altered cancer metabolism and additional roles of some metabolites besides energetic and structural roles.

Keywords:

Metabolism, metabolomics, cancer, MS, NMR

Citation:

Maja Sirotković-Skerlev, MD, PhD. Metabolomics: a systems approach in studying of cancer biology. World Journal of Medical Oncology 2021.