Authors:

WIESER

Les Hopitaux Universitaires de Strasbourg,Grand-Est, France

Abstract:

Mixed neuroendocrine non-neuroendocrine neoplasms (MiNEN) are rare tumors defined as the association of at least two morphologically different neoplastic components, including one neuroendocrine, according to the 2019 World Health Organization (WHO) classification. MiNENs usually originate from organs that contain neuroendocrine cells and in which classical neuroendocrine neoplasms (NEN) are known to develop, such as pancreas, appendix, colon, and to a lesser degree small intestine. However, MiNEN can develop in organs initially lacking in neuro endocrine cells, such as extra and intrahepatic MiNEN, suggesting the existence of different pathological pathways. Due to rarity of hepato-biliary MiNENs, epidemiology, staging, diagnosing and treatment are based on case reports.
In this paper we report the clinical cases of three MiNEN originating from three different sites in the hepatobiliary tract:
i) a first patient with a mixed neuroendocrine tumor and a high grade adenomatous lesion of the ampulla of Vater, ii) a case of a mixed cholangiocarcinoma and NEN of the biliary confluence and
iii) an intrahepatic MiNEN combining a hepatocellular carcinoma with small cell neuroendocrine carcinoma.

Citation:

WIESER. HEPATO-BILIARY MIXED NEUROENDOCRINE NON-NEUROENDOCRINE NEOSPLAMS: 3 CASE REPORTS. World Journal of Medical Oncology 2023.