Correspondence to Author: Shlomi Caduri^1,2, Itzhak Orion². 

1. Department of Nuclear Engineering, Ben-Gurion University of the Negev, POB 653, Beer-Sheva 84105, Israel.
2. Schneider Children’s Medical Center, Kaplan St 14, POB 559, Petah Tikva, Israel, and Rabin Medical Center 39, Jabotinsky St., Petah Tikva 49100, Israel.

DOI: 10.52338/wjoncgy.2025.4465

Abstract:

The accurate evaluation of doses absorbed by organs during 18F-FDG PET scans is a critical issue in operational radiological protection and thus requires the application of the most accurate calculation approaches available. Radiation transport using the Monte Carlo method is the gold standard in medical physics for calculations of dose distributions in complex structures. Recently, positron source Monte Carlo simulation results were compared to measurements and found to be in a good agreement. The current study aims to use EGS5 Monte Carlo simulations to accurately estimate the 18F-FDG absorbed dose to the kidney and to the red bone marrow of the upper arm. The dose obtained from the simulations will be compared to dose values published in reports by the International Commission on Radiological Protection (ICRP). The percentage difference in doses between the Monte Carlo results for the ICRP 106 and ICRP 53 in adult kidneys ranged from 2% to 21%. The absorbed dose Monte Carlo results for arm red bone marrow in children, due to 18FDG injection, were found to be higher by about 2.35%. That dose should be added to the previously estimated total red bone marrow dose. The findings of the present study demonstrate that the estimation of organ absorbed dose based on ICRP dose coefficient involving administration of the 18F-FDG substance is significant for future research, especially regarding radiation protection areas, because it affects the calculation of organ absorbed dose.

Keywords: PET, radiation, dose, positron, imaging.

Citation:

Dr. Itzhak Orion, Evaluation Of Absorbed Dose To Organs From 18F-FDG PET Imaging Using EGS5 Monte Carlo Simulations. World Journal of Medical Oncology 2025.