Correspondence to Author: Ahmet Erhan, 

Başkent University School of Medicine, Alanya Practice and Research Center, Antalya, TurkeyAbstract:

Introduction: Mucinous carcinomas could also be pure or mixed, depending on the physiological state gift. they’re a slow growing tumour, are usually low grade, with rare axillary lymphoid tissue metastases. They have an improved prognosis compared with different invasive carcinomas. Immunohistochemical studies of glycoprotein carcinomas frequently show steroid hormone Receptor (ER) and progestogen Receptor (PR) positivity and human stratum protein receptor-2 (HER-2) negativity.

Case Summary: A 54-year-old feminine consulted because of a step by step enlarging mass on the higher outer quadrant of her right breast. Core biopsy of the mass discovered associate invasive cancer with glycoprotein options. The patient underwent changed radical mastectomy, wherever the ultimate histopathologic designation for the submitted surgical surgical operation specimen was glycoprotein cancer with band cell options, Nottingham microscopic anatomy grade II. Immunohistochemical staining of the core diagnostic test specimen and surgical surgical operation specimen discovered negative steroid hormone and progesterone receptors and positive HER2/neu receptor (3+) in 100% of the tumour cells, that is completely different from the everyday immunohistochemistry profile of glycoprotein breast carcinomas.

Discussion: Pure glycoprotein cancer or mixture carcinomas accounts for no more than a pair of of invasive breast carcinomas and presents with massive amounts of living thing glycoprotein. Between pure and mixed glycoprotein cancer, prognosis is healthier in pure varieties. Modified mastectomy remains the gold commonplace of treatment for breast tumors followed by post-operative endocrine medical care, which is indicated in steroid hormone and progestogen responsive tumors. HER2/neu expression in breast tumors along side the absence of hormone (estrogen and progesterone) receptors is related to an aggressive makeup. once HER-2 is positive, treatment would be trastuzumab, though resistance for glycoprotein carcinomas has been reported.

Conclusion: solely few cases of pure glycoprotein carcinomas area unit positive for HER2 receptors and negative for steroid hormone and progestogen receptors. it’s necessary for physicians to understand that cases of glycoprotein carcinoma positive for HER2 and negative for steroid hormone and progesterone exist and to remember of the clinical issues.

Citation:

Ahmet Erhan. Estrogen and progestin Receptor Negativity and HER-2 positivism in an exceedingly Pure glycoprotein Breast malignant neoplastic disease. World Journal of Medical Oncology 2020.